This study reported its qualitative and quantitative analyses based on lcms method. Screening of leaves and roots of eclipta alba for hepatoprotective activity v. Eclipta alba is a herb commonly found throughout india. Abstract eclipta alba is a herb commonly found throughout india. Antihyperglycemic activity of eclipta alba leaf on alloxaninduced diabetic rats. Thus, ea imparted antioxidant activity by elevating the levels of endogenous antioxidants vitamin e and vitamin c. The previous studies shows that hepatoprotective activity of eclipta alba is by regulating the levels of hepatic microsomal drug metabolizing enzymes saxena ak, et al.
Hepatoprotective activity can be most easily evaluated screened with the aid of several model systems of liver damage in experimental animals. Extracts of eclipta alba were found to be most active against test bacteria, such as s. Reviews by patients who have numbness and take vitamin b6 either as part of daily diet or as method of treatment. Charaka advises taking the juice of eclipta alba with honey to prevent the onset of senility, and its oil as the best medicated massage oils for rejuvenation therapies. Eclipta alba asteraceae is traditional medicinal plant known as bhringaraj. Sugar preferences of avian nectarivores are correlated with intestinal sucrase activity kathryn r. Pharmacological activity reports hepatoprotective activity. Hassk is small branched annual herbaceous plant with a long history of traditional medicines uses in many countries especially in tropical and subtropical. Antiinflammatory constituents from eclipta prostrata using raw264. Acetone, ethanol and methanol extracts showed better activity on test bacterial spp. Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice c. Hassk has been widely used in india for the traditional treatment of liver disorders chopra et al.
Eclipta prostrata is a perennial herb, distributed in the tropical and sub tropical regions of the world. In all test model systems conditions for liver damage are implemented and an attempt is made to counteract this toxicosis. These studies have given several leads to the antimicrobial, diuretic, hypotensive, and hypocholesterolemic activity, antioxidant, anticancer potential, cerebralprotective. Hepatic diseases are a major worldwide health problem, with frequently found in developing countries. Prepared for delivery at the 2007 meeting of the latin american studies association, montreal, canada, september 58, 2007. A study conducted by murugaian p et al in 2008, on the whole plant extract of eclipta alba hassk. Screening of antibacterial and antioxidant activities of leaves of eclipta prostrata l. Tikta, kashaya laghu, ruksha ushna katu kaphavatahara. Evaluation of anti inflammatory activity of eclipta alba in. The present study deals with hepatoprotective activity observed with ethanolic extracts of plant leaves and leaf callus of eclipta alba l. Gst may also be increased, especially in diets with low vitamin e, as it is thought to form gsh conjugates with peroxy radicals miller et al. The loss of hepatic lysomal acid phosphatase and alkaline phosphatase by ccl 4 was significantly restored by eclipta alba.
Activity may be due to the presence of hematinic factors in eclipta alba. Comapartive study on hepatoprotective activity of phyllanthus amarus and eclipta prostrata against alcohol induced in albino rats arun. The presence of chemicals in the aquatic environment have had a significant impact on fish health 24,25,37,38. Alba protected guinea pigs against mortality from carbon tetrachlorideinduced liver damage. Positive and negative experiences from patients with numbness that take vitamin b6. This plant has been well reported to exhibit hepatoprotective activity 2 and in the treatment of infective hepatitis 3. Journal of innovations in pharmaceuticals and biological. Invivo heptoprotective activity of active fraction from.
Eclipta alba bhringaraja having important role in the traditional ayurvedic and unani systems of holistic health and herbal medicine of the east. Physicochemical properties and antiproliferative activity of. Evaluation of hydroalcoholic extract of eclipta alba for its. These herbal drugs have equivalent therapeutic value with the standards drug silymarin. Hepatoprotective activity there have been an extensive studies carried out to substantiate the hepatoprotective activity of eclipta alba. Karunakaran arecanut is an important commercial crop in kerala. The objectives of this study were to i determine the potential use of near infrared reflectance spectroscopy nirs for amino and fatty acid analysis in soybean seed and ii compare nirs amino and fatty acid equations developed with groundseed and wholeseed soybean samples. Extensive research corroborates the hepatoprotective activity of eclipta alba.
Among the two plants aegle marmelos has slightly high activity as compare to eclipta alba. Eclipta alba root extract is considered a powerful liver tonic. Hepatoprotective activity of boerhavia diffusa extract patel monali, verma ramtej department of zoology, university school of sciences, gujarat university, ahmedabad 380009, india. Eclipta alba at a dose of 50 mgkg was studied in ccl 4, paracetamol, and aflatoxininduced hepatic injury, and has shown hepatoprotective activity by reducing the serum ast, and alt. Hepatoprotective and cardiac inhibitory activities of. Ea significantly counteracted ccl 4induced inhibition of the hepatic microsomal drug metabolising enzyme amidopyrine ndemethylase and membrane bound glucose 6phosphatase, but failed to reverse the very high degree of. Chemical composition, pharmacological activities of eclipta alba. Eclipta prostrata ep illustration 1a juice has been showed to inhibit cancer and endothelial cell migration in vitro and to have antiangiogenic activity in vivo5. The plant contains an alkaloid, ecliptine, which has a choleretic action and lipid peroxidation. The loss of hepatic lysosomal acid phosphatase and alkaline phosphatase by ccl4 was significantly restored by eclipta alba. Antianaphylactic activity of alcoholic extract of eclipta alba. Qualitative and quantitative phytochemical analysis of eclipta alba collected from different geographical locations using spectrophotometry, tlchptlc and rphplc. Isolation and characterization of resident endogenous ckit.
An ayurvedic drug from eclipta alba has been found to be quite beneficial for the treatment of jaundice in children dixit and achar,1981. In the chronic model cotton pellet induced granuloma the ceea and standard drug showed decreased formation of granuloma tissue by 49. Journal of innovations in pharmaceuticals and biological sciences. National chengchi university, 64 zhinan road, section 2, wenshan district, taipei 11605, taiwan. The acute toxicity studies have shown that like ea, fraction eaii also high safety margin. Hepatoprotective role of eclipta alba against high fatty. Biherbal ethanolic extract bhee from the leaves of eclipta alba and seeds of piper longum at a dose level of 50 mgkg body weight was. Osmotic and activity coefficient studies on the aqueous solutions of tetramethylurea at 298.
It is bounded by budhi khola in the east, hardiya khola in the west, charkose jungle in the north and khanar and ekamba v. Serum transaminases were also significantly lower in the treated group. It possesses a wide range of biological activities and is used for the treatment of hepatitis and cirrhosis wagner h, 1986 22. The study shows that hepatoprotective activity of eclipta alba is by regulating the levels of hepatic microsomal drug metabolizing enzymes21. It is a nontoxic hepatoprotective substance from the himalaya drug co. Hepatoprotective activities of triphala and its constituents. Effects of eclipta prostrata and eclipta alba on survival. Antibreast tumor activity of eclipta extract invitro and invivo. Components are the individual components to be combined, which can be sources of evidence, retrieval methods, or both i. The present paper describes the phytochemical and pharmacological investigations of eclipta alba.
There are no exclusive markets for the sale of arecanut in kerala. Qualitative and quantitative phytochemical analysis of. Effects of dietary polyunsaturated fatty acidvitamin e pufa. Experimental evaluation of the analgesic property of eclipta alba l hassk. Liver cell injury is generally caused by various toxic chemicals certain antibiotic, chemotherapeutic agents, carbon tetrachloride ccl 4. U 376 international journal of environmental sciences volume 2 no1, 2011 in a test tube containing about 5 ml of plant extract, a drop of sodium bicarbonate was added. The concentration of particles may also vary widely. The plant is an active ingredient of many herbal formulation prescribed for liver ailments and shows effect on liver cell generation 1. It is believed to prevent aging and rejuvenate hair, teeth, bone, memory, sight, hearing. Dec 16, 2012 the physicochemical, catalytic, and antiproliferative activity of a recombinant lasparaginase from yersinia pseudotuberculosis ypa have been studied. Comparative study on hepatoprotective activity of aegle. In indian systems of medicines herbal decoction of eclipta alba is used for the treatment of liver cirrhosis, infective hepatitis liver inflammation due to a viral infection, liver enlargement, and other related diseases of. Exposure to organophosphate pesticides, such as diazinon, can inhibit che activity and it is frequently assumed that decreased activity of che is a biomarker of exposure to these organophosphates.
Eclipta alba also known as bhringraj is small branched annual plant with a long history of ayurvedic medicinal use for rejuvenation and longevity. An ethnomedicinal herb plant, traditionally use in ayurveda. Dasyscyphin c was isolated from eclipta prostrate which were studied on the hela cells for the anticancer activity 12. Eclalbatin, a triterpene saponin from eclipta alba. Particle concentration may be expressed in volumetric or gravimetric terms. Paraskara grhyasutra, kesava paddhati, soundkiya atharva, kousika sathra etc delineate bhrngaraja for its cosmetic as well as medicinal value. Review article ethnopharmacological significance of. Grdds, floating tablet, eclipta alba, hepatoprotective. Eclipta alba is traditionally used as hepatoprotective agent.
Traditional medicinal systems of the indian subcontinent countries as well as tribal practitioners consider the plant to have diverse medicinal values and use it commonly for treatment of gastrointestinal disorders, respiratory tract disorders including asthma, fever, hair loss. Osmotic and activity coefficient studies on the aqueous. Shristi badhani, shivani sharma, amrita kainth, bharat parashar department of pharmacy, manav bharti university, solan, h. The eclipta prostrata extracts significantly inhibited the acute elevation of serum transaminases induced by carbon tetrachloride in mice and by d. Why small crystals are better, ncell requirement, and energy transfer to lattice. The in vitro antifungal activity of eclipta alba whole plant extracts has been investigated against candida tropicalis, rhodotorula glutinis and candida albicans. All the parts of eclipta alba and chemical constituents are used as antileprotic, analgesic, antioxidant, antimyotoxic, antihaemorrhagic, antihepatotoxic, antiviral, antibacterial, spasmogenic. Aqueous extract showed good activity against test spp.
Study reports on the development and characterization of e. Mode of antibacterial activity of eclalbasaponin isolated from eclipta alba. This plant is known to have various pharmacological activities and is traditionally used in treatment but it lacks adequate scientific proof of this activity and constituents responsible for it. Antihyperglycemic activity of eclipta alba leaf on alloxaninduced diabetic rats j ananthi et al yale journal of biology and medicine 76 2003, pp. Eclipta alba extract while neutrophils were also reduced in hepatotoxic control. The inhibitory effects of extracts are very similar to those of standard antibiotics used. The results indicate the potent antiinflammatory effect and therapeutic efficacy of eclipta alba extract on animal models, which is compared with indomethacin. Vedic guard, a polyherbal formulation is a synergistic combination of 16 medicinal plant extracts contains eclipta alba as a major ingredient46. Several of these ethnomedicinal properties have been validated by invitro cellbased as well as animal experiments. Agronomy journal abstract analysis of amino and fatty acid. Nyctaginaceae, commonly known as punarnava is a perennial creeping herb widely studied. The eclipta alba has been extensively studied for its hepatoprotective activity and a number of herbal preparations comprising of eclipta alba are available for treatment of jaundice and other ailments of the liver and gall bladder and viral hepatitis orning et al. Ethnopharmacological significance of eclipta alba l. Multiple telecouplings and their complex interrelationships.
The phytochemical investigation was carried out to determine the possible bioactive components from the methanol extract of eclipta prostrata leaves by gas chromatography and mass spectroscopy gcms. The present study investigates the anticancer and multidrug resistance mdr reversal potential of hydroalcoholic eclipta alba extract eae. Pharmacological activity and chemical constituents of ecliptaalba. Industrial technology development organization, tokyo institute of technology, tokyo, japan. Eclipta alba can be found growing wild in fallow lands of bangladesh where it is considered as a weed by farmers. An alcoholic extract of freshly collected eclipta alba exhibited dosedependent 62. Antibreast tumor activity of eclipta extract invitro and. The structure of eclalbatin has been established as 3obetadglucopyranosyl3betahydroxyolean12en28oic acid, 28obetadarabinopyranoside 1 on the basis of chemical and spectral.
Evaluating the reversal potentials of hydroalcoholic. Pharmacological activity and chemical constituents of. Hepatoprotective activity of ethanolic extract of eclipta. Qualitative and quantitative analysis of eclipta prostrata l. Review accentuating the prodigious significance of eclipta. The extracts of eclipta alba showed high degree of activity against all test fungi. Hepatoprotective activity of some indigenous plants. The protective layer of zebrafish embryo changes continuously with advancing age of embryo development aged. Formulation and estimation of floating tablets of eclipta.
Lal 1, amit kumar 1, prashant kumar 2, kuldeep singh yadav 3 1 department of pharmacy, sagar inst. The experimental protocol was performed as per cpcsea guide lines. Sugar preferences of avian nectarivores are correlated with. Hepatoprotective effects of eclipta alba on subcellular. Evaluation of anti inflammatory activity of eclipta alba in rats. The hepatoprotective activity was monitored by estimating the serum transaminases sgot and sgpt levels and histopathological changes in the liver of experimental animals. Eclipta alba extract eae was prepared by suspending dry. Exploring the determinants of repurchase behavior in c2b ecommerce.
The plant has been reported to exhibit hepatoprotective action on. Hepatoprotective activity of boerhavia diffusa extract. Ashish singh 1, sasikumar menon 1 and sunita shailajan2 presenting author 1institute for advanced training and research in interdisciplinary sciences, 194, scheme. The study shows that hepatoprotective activity ofeclipta alba is by regulating the levels of. Eclipta alba is an important medicinal plant in the traditional system of medicine. However, quality control of this herbal medicine has been not satisfactory.
Tabassum n, agrawal ss 2004 hepatoprotective activity of eclipta alba hassk. Alcoholic extract of the plant is known to show protective effect on experimental liver damage in rats and mice 20. International journal of environmental sciences volume 2 no. Eightyone wistar albino rats were divided into four groups. The effect of various additive excipient was also studied to alter the floating behaviour and drug release from the floating tablet. Hepatoprotective activity of six polyherbal formulations. Jun 14, 2014 eclipta alba ayurvedic herb caraka indicated it for raktapitta while vagbhata advocated its consumption for one month to have the rasayana effect. From the whole plant of eclipta alba, a new triterpene saponin, named eclalbatin, together with alphaamyrin, ursolic acid and oleanolic acid were isolated. Antihyperglycemic activity of eclipta alba leaf on. In vivo evaluation of eclipta alba extract as anticancer and. Wagner h, geyer b, kiso y, hikino h, rao gs 1986 coumestans as the main active principles of the liver drugs eclipta alba and wedella calendulaceae. A rapid densitometric method for quantification of. Accentuating the prodigious significance of eclipta 1260 pak. The present study was undertaken to study the hepato protective.
Comparative study on hepatoprotective activity of aegle marmelos and eclipta alba against alcohol induced in albino rats. Extracts of eclipta alba were found to be most active against test bacteria, such. The model used was carbon tetrachloride ccl 4 induced acute hepatotoxicity in albino rats. Hepatoprotective role of eclipta alba against high fatty diet. The objective of the present study was to evaluate the effect of eclipta alba l. Hepatoprotective activity of eclipta alba is well described in literature 33, 3538. Read hepatoprotective activity of taiwan folk medicine. Exploring the determinants of repurchase behavior in c2b e. I n s t i t u t u m b o t a n i c u m f a c u l t a t i s r e r u m n a t u r a l i u m benatska 2, 128 01 prague 2, czech republic novitates. Fleming 1 1 school of veterinary and life sciences, murdoch university, murdoch, wa 6150. They are mainly caused by uses of high doses of chemicals and some drugs. The study was designed to explore its antiproliferative activity on liver and other related cancer. Haematological protective effect of raw extract and nano.
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