Better delivery was recorded through human epidermis and dermis compared to ellagic acid solution 98. The release study was conducted for all the formulations as shown in figure 2. Candesertan niosomes formulation and evaluation using span 60 as nonionic surafactant p. Dec 26, 2010 a typical niosome vesicle would consist of a vesicle forming ampiphile i. Niosomes were prepared by the thinfilm hydration method and subjected to ultracentrifugation to produce a final concentration of 30 mg of span 60 in 1 ml of niosome suspension. We compared both types of niosomes in their rigidity, permeability, surface tension, thermal properties, toxicity profile, and solubilization by the addition of several aliquots of tr. Studies show that span 60 can form vesicles in the absence or presence of cholesterol, because of its proper hlb and. The greatest skin accumulation was always obtained with nondialyzed vesicular formulations. The bilayers of the vesicles are either in the socalled liquid state or in gel.
Span 60 is a sorbitan monoester than is used as a nonionic detergent. Changes in physical and chemical properties of niosome. Niosomes were prepared by lipid film hydration method. Development and characterization of niosomal drug delivery of. Preparation and properties of vesicles niosomes of sorbitan. According to the results, there was a slight reduction in the ic 50 against the resistant cell line when the drug was encapsulated in span 60 niosomes in comparison. Candesertan niosomesformulation and evaluation using span 60 as nonionic surafactant p. However, niosomes prepared by span 60 and tween 65. Niosomes the nonionic surfactant vesicles, considered as novel drug delivery systems, can improve the solubility and stability of natural pharmaceutical molecules. Acute and subacute toxicity of sorbitan monostearate span. Formulation vitamin c using niosomes system span 80 in gel for increase stability and penetration in vitro pratiwi apridamayanti, nina listiyana, rise desnita of pharmacy, faculty of medicine, university of tanjungpura, pontianak jl. Niosome vesicles would consist of a vesicle making amphiphile i. Preparation and characterization of giant niosomes masters thesis in nanotechnology. In niosomes, the vesicles forming amphiphilic is a nonionic surfactant such as span 60 which is usually stabilized by addition of cholesterol and small amount of anionic surfactant such as dicetyl phosphate.
General characteristics of niosomebiocompatible, biodegradable, non. Tween 61 and span 60 niosomes entrapping diclofenac diethyammonium and embodying 025% ethanol have been developed. Standard niosomes of span 60 and tween 60 with ch were able to drive ellagic acid, a phytochemical substance with potent antioxidant activity, into and through human skin. The activity of doxorubicin in hexadecyl diglycerol ether c 16 g 2 and span 60 niosomes was studied against a human ovarian cancer cell line and its doxorubicin resistant subline. Niosomes were prepared by the thinfilm hydration method and original research article. Navya m n, department of pharmaceutics, bharathi college of pharmacy, bharathi nagar, mandya, karnataka, india. The baclofen niosomes were prepared by altering the ratios between various nonionic surfactants span 60, 40, cholesterol and charge inducing agents using thin film hydration method, the. As per the design different preparations of niosomes were prepared by varying the concentration of span 60 and cholesterol in.
The first report of nonionic surfactant vesicles came from the cosmetic applications devised by loreal buckton et al. International journal of pharmaceutics formulation and. The slower release of drug from multilamellar vesicles may. Kato and coworkers found that the stability of span 80 niosomes is temperaturedependent. Effect of polysorbate 60 on physicochemical properties of. Physicochemical properties and skin permeation of span 60. Apr 12, 2018 for example, a watersoluble drug, such as diclofenac sodium show the maximum loading in niosomes with tween 60, and methotrexate as a hydrophobic drug has maximum entrapment in noisome with span 60 chandraprakash et al. Cholesterol was found to increase the entrapment efficiency of span 60 and span 80 niosomes 4, 5 but also of bolaform surfactants. Formulation and evaluation of etoricoxib niosomes by thin. Application span 60 has been used in a study to assess encapsulation of doxorubicin in niosomes as a route to tumor targeting. The effect of tween 60 and span 60 on the niosome stability may be explained as the following discussion. The vesicles of span 20based niosomes were distinct, near spherical large unilamellar vesicles. The rigidity of the tween 60 niosome membrane is weak due to the high hydrophilicity of tween 60.
Niosomes in comparison with liposomes 27,11 niosomes are now widely studied as an alternative to liposomes, which exhibit certain disadvantages such as they are expensive, their ingredients like phospholipids are. Many factors can influence on niosome construction such as the preparation method, type and amount of surfactant, drug. Niosomes, cholesterol, span 60 and nonionic surfactant. Formulation and evaluation of niosomes indian journal of. Review on span60 based nonionic surfactant vesicles niosomes.
Polysorbate 60 tween 60 and span 60cholesterol melatonin. Formation of multiameliar vesicles niosomes of a series of sorbitan monoest rs span 20,40, 60 and 80 and a sorbitan trioleate span 85 has been studied. Mar 21, 2018 its antimicrobial effect was enhanced when it was incorporated into niosomes that were prepared with varying concentrations of span 60 and cholesterol. Effect of different types of surfactants on the physical properties and. Vesicle size, shape, lamellarity, entrapment efficacy, and in vitro release of azt from niosomes formulated using tween 20, 40, 60 and span 20. Preparation and characterization of giant niosomes. Ramesh department of pharmaceutics, creative educational societys college of pharmacy, chinnatekur, kurnool, india. Niosomes are microscopic in size and their size lies in the nanometric scale. The stability of niosomes has been mostly referred from the timedependent release of watersoluble dyes. Formulation and optimization of zidovudine niosomes ncbi.
Niosomes in comparison with liposomes niosomes are now commonly studied as an unconventional to liposomes, which show certain disadvantages such as they are luxurious, their ingredients like phospholipids are chemically unstable because of their predisposition, oxidative degradation, they have need of unique. Nonionic surfactantbased vesicular system for transdermal drug. International journal of research pharmaceutical and nano. Recent advances in nonionic surfactant vesicles niosomes. The mean size of niosomes increases proportionally with increase in the hydrophiliclipophilic balance hlb of surfactants such as span 85 hlb 1. The vesicle sizes of the niosomes after extrusion were 124752 nm with pi less than 0. Feb 28, 2012 the vesicle sizes of the niosomes after extrusion were 124752 nm with pi less than 0.
Spans span 60, 40, 20, 85, 80 tweens tween 20, 40, 60, 80 and brijs brij 30, 35, 52, 58, 72, 76. Span 60, non ionic multiple sizes available sorbitan. Its antimicrobial effect was enhanced when it was incorporated into niosomes that were prepared with varying concentrations of span 60 and cholesterol. This is because niosomes are able to interact with the bacterial cell envelope, thereby facilitating the diffusion of constituents of propolis across the cell wall. They are established to provide targeting and controlled release of natural pharmaceutical compounds. The particle sizes of span 40 niosomes and span 60 niosomes were 242. Distribution, metabolism and tumoricidal activity of. Plasma doxorubicin was fractionated by gel filtration.
Definition niosomes are synthetic microscopic vesicles consisting of an aqueous core enclosed in a bi layer consisting of cholesterol and one or more nonionic surfactants vesicles are prepared from self assembly of hydrated non ionic surfactants molecules 5. Adjuvanticity, multilamellar vesicles, niosome, span 20, vesicle diameter niosomes are vesicles composed of nonionic surfaceactive agent bilayers, which serve as novel drug delivery systems. International journal of research in pharmaceutical and nano sciences journal homepage. Nonionic surfactantbased vesicular system for transdermal. Cholesterol, which has a property to abolish the gel to liquid transition of niosomes, has found to prevent the leakage of drug from the niosomal formulation.
Niosomes prepared from 50 and 40% of the cholesterol with 25 or 30% of span tween 60 showed the highest stability due to their high. Candesertan niosomesformulation and evaluation using span 60. Table 1 the compositions of blank niosomes bn and melatonin niosomes mn composed of sorbitan monostearate 60 span, cholesterol chol and polysorbate 60 ps. Size and stability of curcumin niosomes from combinations of.
Pdf preparation and properties of vesicles niosomes of. Niosomes have more penetrating capability than the previous preparations of emulsions. Formulation and evaluation of etoricoxib niosomes by thin film hydration technique and ether injection method. The non ionic surfactants possess a hydrophilic head and a. However, niosomes prepared by span 60 and tween 65 exhibited higher permeation and retention of ibuprofen, respectively. Acute and subacute toxicity of sorbitan monostearate span 60. The primary aim was to investigate the acute toxicity of span 60 niosomes after single intraperitoneal ip as well as once daily bolus dose for 5 days. The vesicles were of varied sizes 60 and span 60 affected the size and the stability of the niosomes. Niosomes were prepared using span 80 and tween 80 with or without cholesterol, and several structural studies were done.
The most stable and highest entrapped formulation was 2. Polysorbate 60 used and the codes of each formula are shown in table 1. Size and stability of curcumin niosomes from combinations of tween 80 and span 80. Candesertan niosomesformulation and evaluation using span. Ramesh department of pharmaceutics, creative educational societys college of. The concept of incorporating the drug into niosomes for a better. The contents of tween 60 and span 60 affected the size and the stability of the niosomes.
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